A CLEAR Upfront Winner in Advanced RCC?

Pembrolizumab (Keytruda) plus lenvatinib (Lenvima) improved survival outcomes and response rates as a first-line treatment for advanced renal cell carcinoma (RCC), the randomized phase III CLEAR study showed.

For the primary endpoint, median progression-free survival (PFS) reached a whopping 23.9 months with the anti-PD-1 immunotherapy plus VEGFR tyrosine kinase inhibitor (TKI) combination, as compared with 9.2 months with sunitinib (Sutent), the prior standard in advanced RCC (HR 0.39, 95% CI 0.32-0.49, P

Read More

Add Comment